![]() In 2016, an estimated 216 million people contracted malaria worldwide and 445,000 died from the disease (mostly children in the African Region), according the US Centers for Disease Control. Millions of people each year contract malaria, Zika fever and other insect-borne diseases that are particularly prevalent in tropical and sub-tropical regions. "Our findings suggest that isoxazolines might be effective at controlling outbreaks of diseases carried by mosquitoes and other insects in regions with limited medical infrastructure." "Insect-borne infectious diseases remain primary causes of severe illnesses and fatalities worldwide, and new approaches to preventing outbreaks of these diseases are critically needed," said Peter Schultz, PhD, chief executive officer of Calibr and Scripps Research. ![]() The results of the study were published today in the Proceedings of the National Academy of Sciences. and Calibr's Matt Tremblay, Ph.D., determined via experimental studies on mosquitoes and computer modeling that giving isoxazoline drugs to less than a third of the population in areas prone to seasonal outbreaks of insect-borne diseases could prevent up to 97 percent of all cases of infection. The research team, led by TropIQ's Koen Dechering, Ph.D. The researchers found that a class of drugs called isoxazolines, sold in veterinary products such as fluralaner (Bravecto ) and afoxolaner (NexGard ) to protect pets from fleas and ticks, also kills species of disease-carrying mosquitoes that feed on human blood.
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